Parallel Deferred Update Replication

Deferred update replication (DUR) is an established approach to implementing highly efficient and available storage. While the throughput of read-only transactions scales linearly with the number of deployed replicas in DUR, the throughput of update transactions experiences limited improvements as replicas are added. This paper presents Parallel Deferred Update Replication (P-DUR), a variation of classical DUR that scales both read-only and update transactions with the number of cores available in a replica. In addition to introducing the new approach, we describe its full implementation and compare its performance to classical DUR and to Berkeley DB, a well-known standalone database

High performance deferred update replication

Replication is a well-known approach to implementing storage systems that can tolerate failures. Replicated storage systems are designed such that the state of the system is kept at several replicas. A replication protocol ensures that the failure of a replica is masked by the rest of the system, in a way that is transparent to its users. Replicated storage systems are among the most important building blocks in the design of large scale applications. Applications at scale are often deployed on top of commodity hardware, store a vast amount of data, and serve a large number of users. The larger the system, the higher its vulnerability to failures. The ability to tolerate failures is not the only desirable feature in a replicated system. Storage systems need to be efficient in order to accommodate requests from a large user base while achieving low response times. In that respect, replication can leverage multiple replicas to parallelize the execution of user requests. This thesis focuses on Deferred Update Replication (DUR), a well-established database replication approach. It provides high availability in that every replica can execute client transactions. In terms of performance, it is better than other replication techniques in that only one replica executes a given transaction while the other replicas only apply state changes. However, DUR suffers from the following drawback: each replica stores a full copy of the database, which has consequences in terms of performance. The first consequence is that DUR cannot take advantage of the aggregated memory available to the replicas. Our first contribution is a distributed caching mechanism that addresses the problem. It makes efficient use of the main memory of an entire cluster of machines, while guaranteeing strong consistency. The second consequence is that DUR cannot scale with the number of replicas. The throughput of a fully replicated system is inherently limited by the number of transactions that a single replica can apply to its local storage. We propose a scalable version of the DUR approach where the system state is partitioned in smaller replica sets. Transactions that access disjoint partitions are parallelized. The last part of the thesis focuses on latency. We show that the scalable DUR-based approach may have detrimental effects on response time, especially when replicas are geographically distributed. The thesis considers different deployments and their implications on latency. We propose optimizations that provide substantial gains in geographically distributed environments

Renal Fibrosis in Lupus Nephritis

Fibrosis can be defined as a pathological process in which deposition of connective tissue replaces normal parenchyma. The kidney, like any organ or tissue, can be impacted by this maladaptive reaction, resulting in persistent inflammation or long-lasting injury. While glomerular injury has traditionally been regarded as the primary focus for classification and prognosis of lupus nephritis (LN), increasing attention has been placed on interstitial fibrosis and tubular atrophy as markers of injury severity, predictors of therapeutic response, and prognostic factors of renal outcome in recent years. This review will discuss the fibrogenesis in LN and known mechanisms of renal fibrosis. The importance of the chronicity index, which was recently added to the histological categorization of LN, and its role in predicting treatment response and renal prognosis for patients with LN, will be explored. A better understanding of cellular and molecular pathways involved in fibrosis in LN could enable the identification of individuals at higher risk of progression to chronic kidney disease and end-stage renal disease, and the development of new therapeutic strategies for lupus patients

Concorso per la riqualificazione del sagrato e il restauro della facciata della Basilica Cattedrale di Sant’Agapito Martire in Palestrina

La nuova configurazione mira a ricostituire l’unità tra sagrato e strada attraverso una piena integrazione dei due spazi. La rinnovata articolazione spaziale del sagrato lo rende finalmente adeguato ad ospitare le celebrazioni e le cerimonie religiose, permettendo alla cittadinanza di raccogliersi senza impedimenti attorno all'ingresso della Basilica Cattedrale. Dalla via pubblica si accede al piano del sagrato per mezzo di una gradinata continua in travertino che corre ininterrottamente lungo tutto il perimetro libero. Questa gradinata, oltre a garantire il raccordo tra la quota del sagrato e quella della strada, permette di riconoscere il suolo consacrato senza tuttavia compromettere la totale permeabilità del suo recinto. Obiettivo della proposta progettuale è anche l’armonizzazione delle diverse istanze storiche, archeologiche, artistiche e liturgiche che compongono la facciata. Al fine di ricongiungere visivamente l’area compresa tra i due timpani in un’immagine unitaria, la proposta prevede di rivestire questa porzione di muratura con degli elementi in peperino simili a quelli impiegati per i risarcimenti murari utilizzati nel restauro degli anni ‘50. In questo modo oltre a reintegrare la porzione più alta della facciata al resto del corpo di fabbrica, si ambisce ad alleggerire l’attacco al cielo ottenendo così una più coerente continuità visiva. L’iscrizione dedicatoria è incisa direttamente sulle lastre di pietra con un adeguato sottosquadro in modo tale che sia la proiezione dell’ombra, e non un ennesimo cambio di colore e materiale, a determinarne la leggibilità. Per lo stesso principio lo sporto del tetto viene ridimensionato attraverso un taglio della soletta di copertura in cemento armato rivestito con il medesimo travertino comune alle altre parti

NetPaxos: Consensus at Network Speed

This paper explores the possibility of implementing the widely deployed Paxos consensus protocol in network devices. We present two different approaches: (i) a detailed design description for implementing the full Paxos logic in SDN switches, which identifies a sufficient set of required OpenFlow extensions; and (ii) an alternative, optimistic protocol which can be implemented without changes to the OpenFlow API, but relies on assumptions about how the network orders messages. Although neither of these protocols can be fully implemented without changes to the underlying switch firmware, we argue that such changes are feasible in existing hardware. Moreover, we present an evaluation that suggests that moving Paxos logic into the network would yield significant performance benefits for distributed applications

Mapping Orientational Order of Charge-Probed Domains in a Semiconducting Polymer

Structure–property relationships are of fundamental importance to develop quantitative models describing charge transport in organic semiconductor based electronic devices, which are among the best candidates for future portable and lightweight electronic applications. While microstructural investigations, such as those based on X-rays, electron microscopy, or polarized optical probes, provide necessary information for the rationalization of transport in macromolecular solids, a general model predicting how charge accommodates within structural maps is not yet available. Therefore, techniques capable of directly monitoring how charge is distributed when injected into a polymer film and how it correlates to structural domains can help fill this gap. Supported by density functional theory calculations, here we show that polarized charge modulation microscopy (p-CMM) can unambiguously and selectively map the orientational order of the only conjugated segments that are probed by mobile charge in the few nanometer thick accumulation layer of a high-mobility polymer-based field-effect transistor . Depending on the specific solvent-induced microstructure within the accumulation layer, we show that p-CMM can image charge-probed domains that extend from submicrometer to tens of micrometers size, with markedly different degrees of alignment. Wider and more ordered p-CMM domains are associated with improved carrier mobility, as extracted from device characteristics. This observation evidences the unprecedented opportunity to correlate, directly in a working device, electronic properties with structural information on those conjugated segments involved in charge transport at the buried semiconductor–dielectric interface of a field-effect device